Patient Offices
- Address
-
5 East 98th Street, 10th Floor
New York, NY 10029
- Tel
- 212-241-5656
- Fax
- 212-241-8866
- Office Hours
- Monday 9:00 AM - 5:00 PM
- Tuesday 9:00 AM - 5:00 PM
- Wednesday 9:00 AM - 5:00 PM
- Thursday 9:00 AM - 5:00 PM
- Friday 9:00 AM - 5:00 PM
- Disabled Access
- Yes
Insurance Plans Accepted
- Aetna POS
- Aetna PPO
- Amerigroup
- BCBS Child Health Plus
- BCBS Direct HMO
- BCBS Direct POS
- BCBS Direct Pay HMO
- BCBS Direct Pay HMO/POS
- BCBS DirectShare POS
- BCBS EPO
- BCBS Empire Prism EPO
- BCBS Empire Prism PPO
- BCBS HMO
- BCBS Health New York
- BCBS Indemnity
- BCBS PPO
- Beech Street
- CIGNA Healthcare HMO
- Choice Care
- Cigna - PPO
- Cigna EPO
- Cigna POS
- Devon Health Services
- Fidelis Care NY - HMO
- First Health
- Group Health Insurance (GHI) - HMO
- Group Health Insurance (GHI) - PPO
- HIP Commercial
- HIP Medicaid
- HIP Medicare
- HealthFirst/Medicaid HMO
- HealthNet
- HealthPlus, Inc.
- Island Group
- Local 1199
- Magnacare
- MedCare International
- Medicaid
- Medicaid New Jersey
- Medicare
- MetroPlus Health Plan
- Mount Sinai United Health Care Top Tier
- Multiplan/PHCS
- Neighborhood Health Providers, LLC
- Oxford Freedom
- Oxford Liberty
- Travel Care Services
- United Health Care Commercial
- United Health Care Empire Plan
Disclaimer - Please note that the insurance accepted list may not be complete. Prior to scheduling an appointment, please contact the doctors' office to verify their participation in your plan.
Gwen S. Skloot
ASSOCIATE PROFESSOR Medicine, Pulmonary, Critical Care and Sleep Medicine
Overview
| Subspecialty |
Pulmonary Disease
|
| Clinical Interests |
Asthma |
| |
Emphysema |
| |
Bronchitis |
| |
Chronic Obstructive Pulmonary Disease/COPD |
| Languages |
English |
| |
Spanish |
| Gender |
Female |
| E-mail |
gwen.skloot@mountsinai.org |
| Education and Training |
MD, New York University |
| |
Internship, Internal Medicine, Mount Sinai Hospital |
| |
Residency, Internal Medicine, Mount Sinai Hospital |
| |
Fellowship, Pulm & Critical Care, Johns Hopkins Hospital |
News
Mount Sinai Study Finds One Quarter of WTC Responders Continue to Have Lung Function Impairment
Find out more here
Training
| Education and Training |
MD, New York University |
| |
Internship, Internal Medicine, Mount Sinai Hospital |
| |
Residency, Internal Medicine, Mount Sinai Hospital |
| |
Fellowship, Pulm & Critical Care, Johns Hopkins Hospital |
| Board Certification |
Pulmonary Disease |
Clinical Practice
| Subspecialty |
Pulmonary Disease
|
| Clinical Interests |
Asthma |
| |
Emphysema |
| |
Bronchitis |
| |
Chronic Obstructive Pulmonary Disease/COPD |
| Languages |
English |
| |
Spanish |
| Board Certification |
Pulmonary Disease |
Research
Airway Responsiveness in Asthma
Our laboratory focuses on clinical asthma studies. We hypothesize that hyperresponsiveness is caused by impairment in the ability of inspiration to stretch airway smooth muscle (ASM) -- i.e. impaired bronchodilation. This hypothesis is supported by our finding that sensitivity to the constrictor agent Methacholine is the same in normals and asthmatics when challenge is conducted without deep breaths. It is also known that deep inspiration (DI) prior to a constrictor agent is bronchoprotective in normal subjects. We have shown that this effect relates to inspiratory velocity, i.e. a fast DI is more bronchoprotective than a slow DI. We speculate that in healthy subjects, DI stretches ASM and breaks cross bridges and that cross bridge breakage is enhanced with increased inspiratory velocity. In asthmatics, inflammation may impair this ability. Further protocols will focus on the mechanism of the impaired response to DI in asthma in order to ultimately develop interventions to treat this aspect of hyperresponsiveness.
We have developed an in vitro model to test similar ideas. We hypothesize that stretching guinea pig (GP) tracheal smooth muscle releases a humoral "relaxant" factor [i.e. stretch-induced relaxation (SIR) involves a receptor-mediated mechanism]. The analogous in vivo situation may be the release of a "bronchodilating" substance when a normal subject takes a deep breath. This bronchodilating substance may be decreased in asthma. We have demonstrated that GP tracheal smooth muscle does relax when stretched; this relaxation is enhanced post-carbachol. We have characterized this relaxation response by pharmacokinetic studies. Additional characterization studies are focused on inhibiting the SIR response with agents such as beta-blockers, indomethacin, etc. We have shown that after induction of airway inflammation, the SIR response is reduced. Future protocols will address the mechanism of this reduced response and the relevance to human asthma.
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